Diacetyl Boldine Diacetyl Boldine
Diacetyl Boldine is a synthetic active ingredient derived from boldo tree (Peumus boldus) extracts, with strong brightening and antioxidant action. It works by selectively inhibiting tyrosinase — the enzyme responsible for melanin synthesis in melanocytes — without the cytotoxic effect seen with hydroquinone. It effectively reduces sun spots, melasma, age spots and post-inflammatory hyperpigmentation (PIH). It also acts as an antioxidant, protecting the skin from free radicals and preventing the formation of new discolouration. An ideal ingredient for skin with hyperpigmentation and photoaging, and for those seeking a safe alternative to aggressive brightening methods — used, among others, in Christina's Illustrious line.
BRIGHTENING1% Lumiskin: 32% reduction in discolouration over 8 weeks (chromameter, n=21, Sederma study). Efficacy comparable to 4% hydroquinone without adverse effects.
It selectively inhibits tyrosinase activity in melanocytes (IC50 ~0.3 mM) without a cytotoxic effect. It does not inhibit melanocyte proliferation (unlike hydroquinone).



















